Brief Report LYMPHOID NEOPLASIA SET-NUP214 is a recurrent gd lineage-specific fusion transcript associated with corticosteroid/chemotherapy resistance in adult T-ALL
نویسندگان
چکیده
SET-NUP214 is a recurrent gd lineage-specific fusion transcript associated with corticosteroid/chemotherapy resistance in adult T-ALL Raouf Ben Abdelali, Anne Roggy, Thibaut Leguay, Agata Cieslak, Aline Renneville, Aurore Touzart, Anne Banos, Edouard Randriamalala, Denis Caillot, Bruno Lioure, Alain Devidas, Hossein Mossafa, Claude Preudhomme, Norbert Ifrah, Hervé Dombret, Elizabeth Macintyre, and Vahid Asnafi
منابع مشابه
NUP214 fusion genes in acute leukemia (Review)
Nucleoporin 214 (NUP214), previously termed CAN, is required for cell cycle and nucleocytoplasmic transport. The genetic features and clinical implications of five NUP214-associated fusion genes are described in this review. SET-NUP214 was most frequently observed in T-cell acute lymphoblastic leukemia (T-ALL), concomitant with the elevated expression of HOXA cluster genes. Furthermore, the fus...
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BACKGROUND SET-NUP214 fusion resulting from a recurrent cryptic deletion, del(9)(q34.11q34.13) has recently been described in T-cell acute lymphoblastic leukemia (T-ALL) and in one case of acute myeloid leukemia (AML). The fusion protein appears to promote elevated expression of HOXA cluster genes in T-ALL and may contribute to the pathogenesis of the disease. We screened a panel of ALL and AML...
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T-cell acute lymphoblastic leukemia (T-ALL) is mostly characterized by specific chromosomal abnormalities, some occurring in a mutually exclusive manner that possibly delineate specific T-ALL subgroups. One subgroup, including MLL-rearranged, CALM-AF10 or inv (7)(p15q34) patients, is characterized by elevated expression of HOXA genes. Using a gene expression-based clustering analysis of 67 T-AL...
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The present study aimed to evaluate the therapeutic efficacy of dasatinib in a patient with nucleoporin 214-tyrosine protein kinase ABL1 proto-oncogene 1 (NUP214-ABL1)-positive early T-cell precursor-acute lymphoblastic leukemia (ETP-ALL), as well as that of selinexor and dasatinib for NUP214-ABL1-positive ETP-ALL in vitro. ETP leukemia is a form of T-cell ALL (T-ALL) with poor prognosis. The N...
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The present case report describes a 46-year-old female patient diagnosed with M4 acute myeloid leukemia (AML), accompanied with a t(1;9)(p22;q34) chromosomal abnormality. Transcriptome sequencing identified a DEK proto-oncogene (DEK)/nucleoporin (NUP)214 fusion gene, which results from the t(6;9)(p23;q34) chromosomal translocation. Polymerase chain reaction analysis and fluorescence in situ hyb...
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